The effect of different concentrations of cerium oxide during pregnancy on ovarian follicle development in neonatal mice. Issue 4 (30th November 2020)

• Record Type: Journal Article
• Authors: Nemati, Afsaneh; Beyranvand, Fatemeh; Assadollahi, Vahideh; Salahshoor, Mohammad Reza; Alasvand, Masoud; Gholami, Mohammad Reza
• Is Part Of: Birth defects research. Volume 113:Issue 4(2021)
• Page Start: 349
• Page End: 358
• Publication Date: 2020-11-30
• Subjects: cerium oxide -- malondialdehyde -- neonate -- ovarian -- pregnant mice; Teratology -- Periodicals; Abnormalities, Human -- Periodicals; Congenital Abnormalities; Embryo, Mammalian -- abnormalities; Teratology; Abnormalities, Human; Teratology; Periodicals; Periodicals; 616.043
• DOI: 10.1002/bdr2.1844
• Languages: English
• ISSNs: 2472-1727

Abstract

Abstract: Objectives: Cerium is a member of the rare metals group and widely used in drug delivery, gene therapy, molecular imaging and medicine. In this study, we investigated the effect of different doses of Cerium (IV) oxide (CeO2 ) during pregnancy on neonatal mice ovaries, as well as its effect on blood biochemical parameters. Methods: Thirty pregnant NMRI mice were divided into five groups: Control and 4 groups treated with CeO2 (10, 25, 80, 250 mg/kg.bw i.p) at the GD7 and GD14. The ovarian histological of neonatal (2 and 6 day‐olds), as well as blood serum of neonates at 15‐dpp were analyzed. Results: Count of ovarian primordial follicles in neonates at 2 dpp showed a significant decrease in the groups treated with 80 and 250 mg/kg.bw doses of CeO2 . There was also a significant decrease in ovarian primordial and primary follicles in neonates at 6‐dpp at 250 mg/kg.bw doses of CeO2 in the control ( P < 0.05). There was no significant difference in serum levels of malondialdehyde and total antioxidant capacity between the experimental and control groups. Conclusions: Our results suggest that the effects of CeO2 on the ovarian tissue of neonatal mice during pregnancy may be dose‐dependent.