(-)-Grandiflorimine, a new dibenzopyrrocoline alkaloid with cholinesterase inhibitory activity from Illigera grandiflora. Issue 5 (4th March 2021)

• Record Type: Journal Article
• Authors: Li, Xuejiao; Dong, Jianwei; Gan, Dong; Zhou, Dijiao; Cai, Xueyun; Cai, Le; Ding, Zhongtao
• Is Part Of: Natural product research. Volume 35:Issue 5(2021)
• Page Start: 763
• Page End: 769
• Publication Date: 2021-03-04
• Subjects: Illigera grandiflora -- (-)-grandifloramine -- dibenzopyrrocoline alkaloid -- cholinesterase inhibitory activity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1608542
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: A new dibenzopyrrocoline alkaloid, (-)-grandifloramine (1 ), together with five known ones, actinodaphnine (2 ), N -methyllaurotetanine (3 ), boldine (4 ), lindcarpine (5 ), and (+)-norboldine (6 ), were isolated from Illigera grandiflora W. W. Sm. et J. F. Jeff. The structure of 1 was identified by HRESIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound 1 and 2 exhibited the moderate inhibitory activity against acetylcholinesterase and 3 showed moderate butyrylcholinesterase inhibitory activity. This is the first report of the chemical constituents of I. grandiflora . Abstract :