Sesquiterpenoids from the roots and rhizomes of Valeriana amurensis and their effects on NGF-induced neurite outgrowth in PC12 cells. Issue 5 (4th March 2021)

• Record Type: Journal Article
• Authors: Dong, Fa-Wu; Li, Fang; Ren, Jia-Jia; Zhao, Cheng-Mei; Diao, Hong-Li; Li, Bao-Jing; Li, Yan-Ping; Hu, Jiang-Miao; He, Hong-Ping
• Is Part Of: Natural product research. Volume 35:Issue 5(2021)
• Page Start: 757
• Page End: 762
• Publication Date: 2021-03-04
• Subjects: Valeriana amurensis -- sesquiterpenoids -- central nervous system -- PC12 cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1603223
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Two new sesquiterpenoids, including a kessane-type sesquiterpenoid (1 ) and one bisabolane derivative (2 ), together with fourteen known sesquiterpenoids (3 –16 ), were isolated from the roots and rhizomes of Valeriana amurensis . The structures of new compounds were established on the basis of extensive spectroscopic analysis. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells. As a results, four compounds including 10–12 and 15 showed potent promoting effects at the concentration of 10 µM on NGF-induced neurite outgrowth in PC12 cells with the differentiation rate of 11.84%, 12.21%, 13.77% and 12.16%, respectively. Graphical Abstract: