In vitro study on α-amylase and α-glucosidase inhibitory activities of a new stigmastane-type steroid saponin from the leaves of Vernonia amygdalina. Issue 5 (4th March 2021)

• Record Type: Journal Article
• Authors: Anh, Hoang Le Tuan; Vinh, Le Ba; Lien, Le Thi; Cuong, Pham Viet; Arai, Masayoshi; Ha, Tran Phuong; Lin, Hoang Ngoc; Dat, Ton That Huu; Cuong, Le Canh Viet; Kim, Young Ho
• Is Part Of: Natural product research. Volume 35:Issue 5(2021)
• Page Start: 873
• Page End: 879
• Publication Date: 2021-03-04
• Subjects: Vernonia amygdalina -- Asteraceae -- vernomyoside E -- α-amylase inhibitory -- α-glucosidase inhibitory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2019.1607853
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Using various chromatographic separations, four compounds, including one new steroid saponin named vernoamyoside E (1 ), were isolated from the leaves of the Vietnamese medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were established by spectroscopic methods such as 1D- and 2D-NMR, HR-ESI-MS, and HPLC analysis. The inhibitory activities against α-glucosidase and α-amylase of the isolated compounds from V. amygdalina were reported for the first time. The results indicated that compound 1 significantly inhibited both against α-amylase and α-glucosidase activity. Graphical Abstract: