Detection of the SARS-CoV-2 spike protein in saliva with Shrinky-Dink© electrodes. Issue 7 (12th February 2021)

• Record Type: Journal Article
• Authors: Zakashansky, Julia A.; Imamura, Amanda H.; Salgado, Darwin F.; Romero Mercieca, Heather C.; Aguas, Raphael F. L.; Lao, Angelou M.; Pariser, Joseph; Arroyo-Currás, Netzahualcóyotl; Khine, Michelle
• Is Part Of: Analytical methods. Volume 13:Issue 7(2021)
• Page Start: 874
• Page End: 883
• Publication Date: 2021-02-12
• Subjects: Chemistry, Analytic -- Periodicals; Analytical biochemistry -- Periodicals; Chemical laboratories -- Standards -- Periodicals; 543.1905
• DOI: 10.1039/d1ay00041a
• Languages: English
• ISSNs: 1759-9660

Abstract

Abstract : We introduce a simple, scalable, and portable electrochemical aptamer-based system for detection of the SARS-CoV-2 spike protein in saliva with attomolar sensitivity. Abstract : Using the children's toy, Shrinky-Dink©, we present an aptamer-based electrochemical (E-AB) assay that recognizes the spike protein of SARS-CoV-2 in saliva for viral infection detection. The low-cost electrodes are implementable at population scale and demonstrate detection down to 1 ag mL −1 of the S1 subunit of the spike protein.