A class of water-soluble Fe(iii) coordination complexes as T1-weighted MRI contrast agents. Issue 7 (17th February 2021)

• Record Type: Journal Article
• Authors: Wang, Run; An, Lu; He, Jing; Li, Mengmeng; Jiao, Jingjing; Yang, Shiping
• Is Part Of: Journal of materials chemistry. Volume 9:Issue 7(2021)
• Page Start: 1787
• Page End: 1791
• Publication Date: 2021-02-17
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d0tb02716b
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Water-soluble Fe(iii ) coordination complexes were fabricated as T 1 -weighted magnetic resonance imaging contrast agents in vivo . Abstract : Iron-based coordination complexes are showing increasing potential to be alternatives for T 1 -weighted magnetic resonance imaging (MRI) and contribute to the safety of gadolinium-based compounds. In this work, three water-soluble iron-based complexes constructed using catechol ligands exhibiting T 1 -weighted MRI contrast behavior are described. The longitudinal relaxivity ( r 1 ) increase from 0.88 to 1.43 mM −1 s −1 mainly depends on the sizes and the number of water molecules in the second and outer spheres around the discrete complexes.