Lowest aqueous picomolar fluoride ions and in vivo aluminum toxicity detection by an aluminum(iii) binding chemosensor. Issue 8 (11th February 2021)

• Record Type: Journal Article
• Authors: Das, Monojit; Maity, Debdeep; Acharya, Tusar Kanta; Sau, Sudip; Giri, Chandan; Goswami, Chandan; Mal, Prasenjit
• Is Part Of: Dalton transactions. Volume 50:Issue 8(2021)
• Page Start: 3027
• Page End: 3036
• Publication Date: 2021-02-11
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d0dt03901b
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : A water-soluble PET-based chemosensor is developed which can detect Al(iii ) and F − ions up to nano- and picomolar (lowest detection so far) detection limit, respectively, also utilized to establish aluminum-toxicity effect in biological systems. Abstract : Aluminum toxicity in biological systems is a well-known issue yet remains as a prevalent and unsolvable problem due to the lack of proper molecular tools that can detect free aluminum(iii ) or Al(iii ) ions in vivo . Herein, we report a water-soluble photo-induced electron transfer (PET)-based turn-ON/OFF fluorometric chemosensor for the dual detection of Al(iii ) and fluoride ions in aqueous media with a nanomolar (∼1.7 × 10 −9 M) and picomolar (∼2 × 10 −12 M, lowest ever detection so far) detection limit, respectively. Fluoride ions in sea water could be detected as well as the recognition of non-contamination in drinking water. In addition, using live-cell microscopy, Al(iii ) ions were detected in live biological samples in vivo to aid establishing the aluminum-toxicity effect.