Recent advances in Rh(iii)/Ir(iii)-catalyzed C–H functionalization/annulation via carbene migratory insertion. Issue 7 (28th January 2021)

• Record Type: Journal Article
• Authors: Kumar, Sanjeev; Nunewar, Saiprasad; Oluguttula, Srilekha; Nanduri, Srinivas; Kanchupalli, Vinaykumar
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 7(2021)
• Page Start: 1438
• Page End: 1458
• Publication Date: 2021-01-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02309d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The review highlighted diverse annulations, including nitrogen, oxygen, sulfur heterocycles and carbocylizations via Rh(iii )/Ir(iii )-catalyzed C–H functionalization/annulation with various arene and carbene precursors. Abstract : In the past two decades, transition metal-catalyzed C–H functionalization followed by annulations with various coupling partners has received much attention in organic synthesis. In particular, Rh(iii ) or Ir(iii ) catalyzed regioselective C–H functionalization followed by the cyclization of diverse arenes with metal carbene precursors has become a highly investigated research field in recent years. The purpose of this review is to provide a comprehensive essay on the Rh(iii )/Ir(iii ) catalyzed C–H functionalizations/annulations via carbene migratory insertion, focusing on the diverse metal carbene precursors with arenes/alkenes reported so far. The highlighted examples are categorized by nitrogen, oxygen, sulfur-containing heterocycles and carbocyclizations. Further, key mechanistic approaches are also briefly described.