Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. Issue 7 (27th January 2021)

• Record Type: Journal Article
• Authors: Chen, Yan-Ni; Ding, Xiao; Li, Dong-Mei; Sun, Mao; Yang, Lei; Zhang, Yu; Di, Ying-Tong; Fang, Xin; Hao, Xiao-Jiang
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 7(2021)
• Page Start: 1541
• Page End: 1545
• Publication Date: 2021-01-27
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02414g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Three jatrophane diterpenes with an unprecedented ditetrahydropyran 5/5/5/11 tetracyclic ring system and activity in inducing lysosomal biogenesis were isolated from the seeds of Euphorbia peplus . Abstract : Three novel jatrophane diterpenes, cyclojatrophanes A–C (1–3 ), were isolated from the seeds of Euphorbia peplus . Compounds 1–3 featured an unprecedented 5/5/5/11 tetracyclic ring system incorporating ditetrahydropyran rings. Their structures including their absolute configurations were established by extensive spectroscopic analysis, X-ray crystallographic experiments and chemical transformations. In addition, these compounds could significantly activate the lysosomal-autophagy pathway.