Copper-catalyzed oxidative cyclization of glycine derivatives toward 2-substituted benzoxazoles. Issue 7 (3rd February 2021)

• Record Type: Journal Article
• Authors: Liu, Shan; Zhu, Zhi-Qiang; Hu, Zhi-Yu; Tang, Juan; Yuan, En
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 7(2021)
• Page Start: 1616
• Page End: 1619
• Publication Date: 2021-02-03
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02490b
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A novel and direct intramolecular cyclization of glycine derivatives involving short peptides to 2-substituted benzoxazoles via copper-catalyzed oxidative C–H/O–H cross-coupling was described. Abstract : A novel and straightforward intramolecular cyclization of glycine derivatives to 2-substituted benzoxazoles through copper-catalyzed oxidative C–H/O–H cross-coupling was described. A variety of glycine derivatives involving short peptides underwent cross-dehydrogenative-coupling readily to afford diverse 2-substituted benzoxazoles. The synthetic method has the advantages of simple operation, broad substrate scope and mild reaction conditions, thus providing an alternative effective approach for benzoxazole construction.