Lack of association between miR-146a rs2910164 C/G locus and colorectal cancer: from a case–control study to a meta-analysis. Issue 1 (29th January 2021)

• Record Type: Journal Article
• Authors: Jiang, Jiakai; Zhang, Sheng; Tang, Weifeng; Qiu, Zhiyuan
• Is Part Of: Bioscience reports. Volume 41:Issue 1(2021)
• Publication Date: 2021-01-29
• Subjects: Colorectal cancer -- Meta-analysis -- MiR-146a -- Polymorphism -- Risk; Molecular biology -- Periodicals; Cytology -- Periodicals; 572.8
• DOI: 10.1042/BSR20191729
• Languages: English
• ISSNs: 0144-8463

Abstract

Abstract: Previous studies suggested that miR-146a rs2910164 (C/G) locus was predicted to influence the risk of cancer. However, the relationship of miR-146a rs2910164 locus with colorectal cancer (CRC) susceptibility was controversial. We recruited 1003 CRC patients and 1303 controls, and performed a case–control study to clarify the correlation of miR-146a rs2910164 locus with CRC risk. Subsequently, a comprehensive meta-analysis was conducted to verify our findings. In the case–control study, we suggested that miR-146a rs2910164 variants did not alter CRC risk (CG vs. CC: adjusted P =0.465; GG vs. CC: adjusted P =0.436, CG/GG vs. CC: adjusted P =0.387 and GG vs. CC/CG: adjusted P =0.589), even in subgroup analysis. Next, we conducted a pooled-analysis to identify the correlation of miR-146a rs2910164 locus with CRC risk. In this pooled-analysis, 7947 CRC cases and 12, 168 controls were included. We found that miR-146a rs2910164 polymorphism did not influence the risk of CRC (G vs. C: P =0.537; GG vs. CC: P =0.517, CG/GG vs. CC: P =0.520 and GG vs. CC/CG: P =0.167). Our findings suggest that miR-146a rs2910164 C/G polymorphism is not correlated with the susceptibility of CRC. In the future, more case–control studies are needed to confirm our results.