Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease. (1st January 2021)

• Record Type: Journal Article
• Authors: Murugesan, Saravanakumar; Saravanakumar, Lakshmi; Powell, Mark F.; Rajasekaran, Namakkal Soorappan; Kannappan, Ramaswamy; Berkowitz, Dan E.
• Is Part Of: Placenta. Volume 103(2021)
• Page Start: 226
• Page End: 231
• Publication Date: 2021-01-01
• Subjects: exomiR signatures -- Placental remodeling -- Endothelial dysfunction -- Preeclampsia -- Pregnancy; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2020.10.033
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Preeclampsia (PE) and vascular dysfunction are major causes of maternal and neonatal morbidity and mortality. Although extensively studied, the complete understanding of the pathophysiology behind PE remains unclear. Current reports indicate that exosomes are essential mediators in PE-related cardiovascular disease (CVDs). Exosomes are synthesized from multivesicular bodies (MVB) and contain functionally active microRNAs miRNAs). These miRNAs have been shown to mediate physiological and pathological functions through autocrine, paracrine, and endocrine signaling mechanisms. The role of miRNAs in pregnant women with PE has been studied extensively. However, little is known about the effect of exosomal miRNAs (exomiR) in PE. This paper will review and discuss the existing evidence for exomiR function in PE and highlight the need for future studies to explore the role that exomiR signatures have in cardiovascular dysfunction associated with PE. Highlights: Placental derive exosomal miRNAs (exomiR) have emerged as novel intercellular signaling mediators in PE associated CVDs. Circulating exomiR from placenta in PE carry signals that can influence in maternal cardiac complications. Placental derive exomiR from placenta as early biomarkers for PE related disorders.