A rhodium-catalysed conjugate addition/cyclization cascade for the asymmetric synthesis of 2-amino-4H-chromenes. Issue 4 (7th January 2021)

• Record Type: Journal Article
• Authors: Chang, Zhiqian; Zhu, Huilong; Wu, Changhui; Xing, Junhao; Dou, Xiaowei
• Is Part Of: Organic & biomolecular chemistry. Volume 19:Issue 4(2020)
• Page Start: 785
• Page End: 788
• Publication Date: 2021-01-07
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d0ob02404j
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : The enantioselective synthesis of 2-amino-4 H -chromenes is achieved by the cascade rhodium-catalysed asymmetric conjugate addition/hetero Thorpe–Ziegler reaction. Abstract : The enantioselective synthesis of 2-amino-4 H -chromenes via the cascade rhodium-catalysed conjugate addition/hetero Thorpe–Ziegler reaction is reported. Moderate to good yields (up to 98%) and high enantioselectivities (up to 92% ee) were obtained with a chiral diene-coordinated rhodium complex as the catalyst. This protocol remedies the methodological deficiency in the asymmetric synthesis of 4-aryl 2-amino-4 H -chromenes.