Ulmusakidian, a new coumarin glycoside and antifungal phenolic compounds from the root bark of Ulmus davidiana var. japonica. (15th March 2021)

• Record Type: Journal Article
• Authors: Alishir, Akida; Yu, Jae Sik; Park, Minji; Kim, Jin-Chul; Pang, Changhyun; Kim, Jung Kyu; Jang, Tae Su; Jung, Won Hee; Kim, Ki Hyun
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 36(2021)
• Publication Date: 2021-03-15
• Subjects: Ulmus davidiana var. japonica -- Ulmaceae -- Coumarin glycoside -- Antifungal activity; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2021.127828
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: Bioactivity-driven phytochemical analysis of Ulmus davidiana var. japonica was conducted. A new coumarin glycoside derivative, ulmusakidian (1 ) was identified . Nine known phenolic compounds (2 –10 ) were also identified . The antifungal activity of compounds 1 –10 was evaluated against C. neoformans and C. albicans . Compounds 9 and 10 showed antifungal activity against C. neoformans with MIC of 12.5–25.0 µg/mL. Abstract: Bioactivity-driven LC/MS-based phytochemical analysis of the root bark extract of Ulmus davidiana var. japonica led to the isolation of 10 compounds including a new coumarin glycoside derivative, ulmusakidian (1 ) . The structure of the new compound was elucidated using extensive spectroscopic analyses via 1D and 2D NMR spectroscopic data interpretations, HR-ESIMS, and chemical transformation. The isolated compounds 1–10 were tested for their antifungal activity against human fungal pathogens Cryptococcus neoformans and Candida albicans . Compounds 9 and 10 showed antifungal activity against C. neoformans, with the lowest minimal inhibitory concentration (MIC) of 12.5–25.0 µg/mL, whereas none of the compounds showed antifungal activity against C. albicans .