A facile access for multisubstituted trifluoromethyl olefins by visible light catalysis. (2nd March 2021)

• Record Type: Journal Article
• Authors: Ren, Shujian; Fu, Jiahui; Cheng, Dongping; Li, Xiaonian; Xu, Xiaoliang
• Is Part Of: Tetrahedron letters. Volume 66(2021)
• Publication Date: 2021-03-02
• Subjects: Visible light photocatalysis -- Alkylboronic acids -- Multisubstituted trifluoromethyl olefin; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.152829
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Facile synthesis of multisubstituted trifluoromethyl olefins by visible light photoredox. Broad scope of alkylboronic acids and Boc-modified trifluoromethylated Baylis-Hillman adduct. Moderate to good yields, simple operation and mild conditions. Abstract: Induced by visible light, a green approach for the highly substituted trifluoromethyl olefins has been developed by using alkyl boronic acid as a carbon radical precursor and the Boc-modified trifluoromethylated Baylis-Hillman adduct (BMTBHA) as an acceptor. This method starts from 1, 1-disubstituted olefins without the external stoichiometric oxidant.