Copper(I)–NHCs complexes: Synthesis, characterization and their inhibition against the biofilm formation of Streptococcus mutans. (15th March 2021)

• Record Type: Journal Article
• Authors: Pan, Ting; Wang, Yinuo; Liu, Feng-Shou; Lin, Huancai; Zhou, Yan
• Is Part Of: Polyhedron. Volume 197(2021)
• Publication Date: 2021-03-15
• Subjects: Antibacterial -- Streptococcus mutans -- Oral biofilm -- Dental caries -- Copper N-heterocyclic carbenes; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2021.115033
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: A series of well-defined copper-NHCs have been synthesized and characterized. Relationship between the structure of the copper-NHCs and the inhibition effects was investigated, and Copper-NHCs of Cu1 was demonstrated as a broad-spectrum inhibitor to oral bacteria. Abstract: With the goal of developing high-efficiency oral antimicrobial agents to prevent S. mutans biofilm formation, a collection of copper(I)- N -heterocyclic carbenes (NHCs) complexes with different substitutions was synthesized and characterized. Their inhibitory activities of Cu1–Cu7 were screened. It was found that Cu1 provided significant excellent performance, which suggested that the less lipophilic and less sterically hindered copper complexes would be effective towards the bacteria. This study demonstrates the great potential of copper(I)-containing small molecule complexes as broad-spectrum inhibitors to treat oral bacteria, especially for diminishing S. mutans biofilm formation, which opens promising perspectives for the development of new metal-NHCs for controlling the biofilm formation associated with pathogens.