An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections. (March 2021)

• Record Type: Journal Article
• Authors: Leon, Kristoffer; Ott, Melanie
• Is Part Of: Seminars in cell & developmental biology. Volume 111(2021)
• Page Start: 101
• Page End: 107
• Publication Date: 2021-03
• Subjects: Viruses -- RNA biology -- Nonsense-mediated mRNA decay -- Anti-viral response; NMD Nonsense-mediated mRNA Decay -- UPF Up-Frameshift Protein -- SFV Semliki Forest Virus -- SINV Sindbis Virus -- HCV Hepatitis C Virus -- ZIKV Zika Virus -- WNV West Nile Virus -- DENV Dengue Virus -- CoV Coronavirus -- MHV Mouse Hepatitis Virus -- PVX Potato Virus X -- TCV Turnip Crinkle Virus -- PEMV2 Pea Enation Mosaic Virus 2 -- HTLV Human T Lymphotropic Virus -- HIV Human Immunodeficiency Virus -- RSV Rous Sarcoma Virus -- CaMV Cauliflower Mosaic Virus; Cytology -- Periodicals; Developmental biology -- Periodicals; 571.6
• DOI: 10.1016/j.semcdb.2020.05.018
• Languages: English
• ISSNs: 1084-9521

Abstract

Abstract: The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.