Fenton-like reaction, glutathione reduction, and photothermal ablation-built-in hydrogels crosslinked by cupric sulfate for loco-regional cancer therapy. (24th November 2020)

• Record Type: Journal Article
• Authors: Kim, Sungyun; Seo, Ji-Hye; Jeong, Da In; Yang, Mingyu; Lee, Song Yi; Lee, Junmin; Cho, Hyun-Jong
• Is Part Of: Biomaterials science. Volume 9:Number 3(2021)
• Page Start: 847
• Page End: 860
• Publication Date: 2020-11-24
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/d0bm01470b
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : CuSO4 -reinforced hydrogel system was developed for chemodynamic and photothermal therapy of breast cancer. Abstract : Fenton-like reaction-associated chemodynamic therapy (CDT) and hyperthermia-inducing photothermal therapy (PTT)-combined crosslinked hydrogel systems were developed for loco-regional cancer therapy. Cupric sulfate (Cu) has been employed to crosslink the catechol-functionalized hyaluronic acid (HC) polymer-based gel via metal–catechol coordination and covalent bonding of the catechol group (by pH adjustment). Cu can also be used as a hydroxyl radical-generating agent with endogenous H2 O2 in cancer cells mediated by Fenton-like reaction and it can reduce intracellular glutathione (GSH) levels leading to the inhibition of reactive oxygen species (ROS) scavenging. These two strategies can amplify the ROS-initiated CDT efficiency for combating cancer. The Cu-incorporated crosslinked hydrogel structure with pH modulation was appropriate for injectable gel formation via a single syringe. The incorporation of indocyanine green (ICG) into the hydrogel network and near-infrared (NIR) laser irradiation provided a temperature elevation sufficient for induction of hyperthermia in cancer therapy. It is expected that the designed HC/Cu/ICG hydrogel can be used safely and efficiently for local CDT and PTT of breast cancer.