Differential efferent projections of GABAergic neurons in the basolateral and central nucleus of amygdala in mice. (6th February 2021)

• Record Type: Journal Article
• Authors: Liu, Jing; Hu, Tao; Zhang, Meng-Qi; Xu, Chuan-Ying; Yuan, Mao-Yun; Li, Rui-Xi
• Is Part Of: Neuroscience letters. Volume 745(2021)
• Publication Date: 2021-02-06
• Subjects: ACo anterior cortical nucleus -- AD anterodorsal thalamic nucleus -- AM anteromedial thalamic nucleus -- AOM medial part of the anterior olfactory nucleus -- AOP posterior part of anterior olfactory nucleus -- AV anteroventral thalamic nucleus -- BLA basolateral amygdala -- BLV basolateral amygdaloid nucleus -- BMA anterior part of basomedial amygdaloid nucleus -- BST bed nucleus of the stria terminalis -- BSTIA intraamygdaloid division of bed nucleus of the stria terminalis -- BSTLP posterolateral BST -- BSTLV ventrolateral BST -- BSTMV ventromedial BST -- BSTMA anteromedial BST -- BSTMPL medial of posterolateral BST -- BSTMPI medial of posterointer -mediate BST -- BSTMPM medial of posteromedial BST -- BSTS supracapsular BST -- CEA central amygdala -- CeL lateral division of central amygdaloid nucleus -- CeC capsular part of central amygdaloid nucleus -- CeMPV medial posteroventral part of central amygdaloid nucleus -- CL centrolateral thalamic nucleus -- cp cerebral peduncle -- CxA cortico-amygdaloid transition area -- DI dysgranular insular cortex -- DG dentate gyrus -- DTT dorsal tenia tecta -- DpMe deep mesencephalic nucleus -- DpWh deep white layer of the superior colliculus -- Ect entorhinal cortex -- GrDG granular layer of the dentate gyrus -- HDB horizontal limb of the diagonal band -- LC locus coeruleus -- LMol lacunosum moleculare layer of the hippocampus -- LPMR lateral posterior mediorostral thalamic nucleus -- M1 primary motor cortex -- M2 secondary motor cortex -- MCPO magnocellular preoptic nucleus -- MDM medial part of mediodorsal thalamic nucleus -- MePV posteroventral part of medial amygdaloid nucleus -- MG medial geniculate nucleus -- MGM medial part of medial geniculate nucleus -- MGV ventral part of medial geniculate nucleus -- Mol molecular layer of the dentate gyrus -- MPB medial parabrachial nucleus -- MS medial septal nucleus -- MZMG marginal zone of the medial geniculate -- PAG periaqueductal gray -- Pe periventricular hypothalamic nucleus -- Pir piriform cortex -- PLCo posterolateral cortical amygdaloid nucleus -- S1 primary somatosensory cortex -- SI substantia innominate -- SM stria medullaris -- SN substantia nigra -- SNL lateral substantia nigra -- SNC compact of substantia nigra -- StA strial part of the preoptic area -- Tu olfactory tubercle -- VDB vertical limb of the diagonal band -- VP ventral pallidum -- VTT ventral tenia tecta; Basolateral amygdala -- Central amygdala -- GABAergic neurons -- AXonal projections -- VGAT-Cre mice; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2020.135621
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Axonal projections of GABAergic neurons in the BLA distributed to the forebrain. GABAergic neurons in the CEA projected to the forebrain, midbrain and brainstem. Axonal projections of GABAergic neurons in BLA and CEA were mapped and quantified. Abstract: The Basolateral amygdala (BLA) and central nucleus of the amygdala (CEA) have been proved to play a key role in the control of anxiety, stress and fear-related behaviors. BLA is a cortex-like complex consisting of both γ-aminobutyric acidergic (GABAergic) interneurons and glutamatergic neurons. The CEA is a striatum-like output of the amygdala, consisting almost exclusively of GABAergic medium spiny neurons. In this study, we explored the morphology and axonal projections of the GABAergic neurons in BLA and CEA, using conditional anterograde axonal tracing, immunohistochemistry, and VGAT-Cre transgenic mice to further understand their functional roles. We found that the axonal projections of GABAergic neurons from the BLA mainly distributed to the forebrain, whilst GABAergic neurons from the CEA distributed to the forebrain, midbrain and brainstem. In the forebrain, the axonal projections of GABAergic neurons from the BLA projected to the anterior olfactory nucleus, the cerebral cortex, the septum, the striatum, the thalamus, the amygdala and the hippocampus. The axonal projections of GABAergic neurons from the CEA distributed to the nuclei of the prefrontal cortex, the bed nucleus of the stria terminalis, the hypothalamus and the thalamus. In the midbrain and brainstem, the axonal projections of GABAergic neurons from the CEA were found in the periaqueductal gray, the substantia nigra, and the locus coeruleus. These data reveal the neuroanatomical basis for exploring the function of GABAergic neurons in the BLA and CEA, particularly during the processing of fear-related behavior.