Briarenols O and P: Novel briaranes from a cultured octocoral Briareum excavatum (Briareidae). (February 2021)

• Record Type: Journal Article
• Authors: Chi, Wei-Chiung; Kuo, Liang-Mou; Yang, San-Nan; Lee, Yi-Ting; Wen, Zhi-Hong; Tsui, Kuan-Hao; Hwang, Tsong-Long; Zhang, Yi-Lin; Sung, Ping-Jyun
• Is Part Of: Phytochemistry letters. Volume 41(2021)
• Page Start: 134
• Page End: 138
• Publication Date: 2021-02
• Subjects: Briareum excavatum -- Briarane -- Briarenol -- iNOS; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.09.012
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Novel briaranes, briarenols O (1 ) and P (2 ), were obtained from a cultured octocoral B. excavatum . Briarane 1 was found to enhance the protein expression of iNOS. Cultivated B. excavatum is a rich source of briarane-type diterpenoids. Abstract: Two new 3, 8-cyclized cembranoids, briarenols O (1 ) and P (2 ), featuring with briarane carbon skeleton have been isolated from a cultured octocoral Briareum excavatum . The structures of 1 and 2 were established by spectroscopic methods and 1 was found to be a rare 2-ketobriarane. Briarane 1 enhanced the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).