Vinapraesorediosic acids D and E from the lichen Parmotrema praesorediosum (Nyl.) Hale. (February 2021)

• Record Type: Journal Article
• Authors: Huynh, Bui-Linh-Chi; Pham, Nguyen Kim Tuyen; Nguyen, Tan Phat
• Is Part Of: Phytochemistry letters. Volume 41(2021)
• Page Start: 61
• Page End: 64
• Publication Date: 2021-02
• Subjects: Parmotrema praesorediosum -- Parmeliaceae -- Vinapraesorediosic acid D -- Vinapraesorediosic acid E; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2020.11.001
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new acids (1, 2 ) were purified from P. praesorediosum . Their structures were elucidated by spectroscopic methods. The cytotoxicity of 1 was evaluated against four human cancer cell lines. Abstract: One new α, β -unsaturated- γ -lactone acid, named Vinapraesorediosic acid D (1 ), and one new benzoic acid, Vinapraesorediosic acid E (2 ), were isolated from the lichen Parmotrema praesorediosum . Their chemical structures were elucidated by extensive IR, CD, HR-ESI-MS, and NMR spectroscopic analysis, and comparison with previously published data. Compound 1 was evaluated for the cytotoxicity against four human cancer cell lines (MCF-7, HeLa, NCI-H460, and HepG2) using SRB assay. As results, 1 exhibited moderate activity against MCF-7.