Recurrent Gastrointestinal Near-Tetraploid Diffuse Large B-Cell Lymphoma Causing Intussusception and Ileal Ulceration. Issue 7 (July 2019)

• Record Type: Journal Article
• Authors: Mathews, Steven N.; Niec, Rachel; Mathew, Susan; Allan, John N.; Crawford, Carl V.
• Is Part Of: ACG Case Reports Journal. Volume 6:Issue 7(2019)
• Publication Date: 2019-07
• DOI: 10.14309/crj.0000000000000131
• Languages: English
• ISSNs: 2326-3253

Abstract

Abstract : ABSTRACT: Polyploid karyotypes in diffuse large B-cell lymphoma (DLBCL) are rare and carry a poor prognosis. Extranodal polyploid lymphoma is uncommon. A 71-year-old man with back pain was found to have ileal intussusception. He underwent surgical resection and was diagnosed with DLBCL with a near-tetraploid karyotype. Despite rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone therapy, he developed recurrent disease for which he started a clinical trial. He then developed dark stools from an ileal ulcer due to progressive disease and died 2 weeks later. This is the first reported case of gastrointestinal DLBCL with polyploidy. These karyotypes require attention to extranodal disease and prompt initiation of therapy.