Celiac Disease and Secondary Amyloidosis: A Possible Causal Association?. Issue 1 (2018)

• Record Type: Journal Article
• Authors: Chhoda, Ankit; Jain, Deepanshu; Daga, Mradul Kumar; Batra, Vineeta
• Is Part Of: ACG Case Reports Journal. Volume 5:Issue 1(2018)
• Publication Date: 2018
• DOI: 10.14309/crj.2018.24
• Languages: English
• ISSNs: 2326-3253

Abstract

ABSTRACT : N/A: We report a rare case of secondary renal amyloidosis in a patient with probable celiac disease presenting as nephrotic syndrome. A 30‐year‐old man with chronic diarrhea presented with progressive anasarca for 2 years. On further evaluation, he had hypoalbuminemia, significant nephrotic‐range proteinuria, and elevated levels of anti‐tissue transglutaminase. Renal biopsy suggested deposition of amorphous Congo red‐positive material in the glomerular mesangium, positive for amyloid A amyloidosis. Endoscopic duodenal biopsy suggested blunting of the villous architecture and chronic inflammation of the lamina propria. The patient subsequently developed massive pulmonary embolism and died due to refractory cardiogenic shock.