Characterizing the joint effects of pesticide exposure and criteria ambient air pollutants on pediatric asthma morbidity in an agricultural community. Issue 3 (June 2019)

• Record Type: Journal Article
• Authors: Benka-Coker, Wande O.; Loftus, Christine; Karr, Catherine; Magzamen, Sheryl
• Is Part Of: Environmental epidemiology. Volume 3:Issue 3(2019)
• Publication Date: 2019-06
• Subjects: Pollutant mixtures -- Agricultural settings -- Pediatric asthma -- Biomarkers; Epidemiology -- Periodicals; Epidemiology -- Environmental aspects -- Periodicals; 614.4
• DOI: 10.1097/EE9.0000000000000046
• Languages: English
• ISSNs: 2474-7882

Abstract

Abstract : Background: Environmental contributions to pediatric asthma morbidity have been studied extensively in urban settings; exposures characteristic of agricultural and rural communities have received less attention despite a comparable burden of morbidity. Methods: We obtained repeated urine samples (n = 139) from 16 school-age children with asthma in the Yakima Valley of Washington State between July and October 2012. Biomarkers of organophosphate (OP) pesticide exposure (dialkyl phosphates [DAPs]) and asthma exacerbation (leukotriene E4 [LTE4]) were analyzed in samples. Corresponding 24-hour average particulate matter <2.5 μg (PM2.5 ) and maximum 8-hour ozone concentration data for the study period were available from local monitoring stations. We evaluated the independent and multi-pollutant associations between LTE4 and exposure to ambient air pollutants and DAPs using generalized estimating equations. For multi-domain and multi-pollutant models, we created categorized pollution combination levels and estimated the relative health impact of exposure to pollutant mixtures. Results: In single-pollutant models, an interquartile range increase in exposures to DAPs was associated with increase in LTE4 levels (β: 4.1 [0.6–7.6] pg/mg). PM2.5 and ozone were also associated with increase in LTE4, though confidence intervals contained the null value. Increase in LTE4 levels was consistently associated with increase in median-dichotomized multi-pollutant combination exposures; the highest effect estimates were observed with joint highest (vs. the lowest) category of the three-pollutant exposure (PM2.5, ozone, and OP; β: 53.5, 95% confidence interval = 24.2, 82.8 pg/mg). Conclusion: Concurrent short-term exposure to criteria air pollutants and OPs in an agricultural community was associated with an increase in a marker of asthma morbidity. Abstract : Supplemental Digital Content is available in the text.