The benefit of individualized low‐dose hCG support for high responders in GnRHa‐triggered IVF/ICSI cycles. Issue 7 (July 2016)

• Record Type: Journal Article
• Authors: Huang, Chen‐Yu; Shieh, Miawh‐Lirng; Li, Hsin‐Yang
• Is Part Of: Journal of the Chinese Medical Association. Volume 79:Issue 7(2016)
• Publication Date: 2016-07
• Subjects: agonist trigger -- high responders -- human chorionic gonadotropin (hCG) -- in vitro fertilization (IVF) -- ovarian hyperstimulation syndrome (OHSS); Medicine -- Periodicals; 610.5
• DOI: 10.1016/j.jcma.2016.02.006
• Languages: English
• ISSNs: 1726-4901

Abstract

Abstract : Background : To assess the pregnancy outcome and ovarian hyperstimulation syndrome (OHSS) incidence in high responders receiving gonadotropin‐releasing hormone agonist (GnRHa) trigger plus individualized support of low‐dose human chorionic gonadotropin (hCG). Such support includes 500–1000 IU hCG given at trigger and, if serum estradiol (E2 ) dropped to below 800 pg/mL before the 6 th day after oocyte retrieval, an additional rescue dose of 300 IU hCG. Methods : This was a retrospective study of potential high responders aged from 28 years to 40 years at a tertiary fertility center in Taiwan. By means of chart review, we assessed the pregnancy outcome and OHSS incidence in high responders receiving GnRHa trigger plus individualized low‐dose hCG support. The main outcomes were measured by ongoing pregnancy rate and OHSS incidence (SPSS), in which statistical significance was determined by Chi‐square test. Results : Moderate to severe OHSS did not develop in any patient receiving GnRHa trigger plus individualized low‐dose hCG support. In fact, a satisfactory ongoing pregnancy rate (46.9%) was noted in patients receiving GnRHa trigger plus individualized low‐dose hCG support. Conclusion : Our study suggested that GnRHa trigger combined with individualized low‐dose hCG support appears to be a safe approach with a satisfactory pregnancy outcome.