Mirtazapine for Refractory Gastroparesis. Issue 10 (October 2019)

• Record Type: Journal Article
• Authors: Marella, Hemnishil K.; Saleem, Nasir; Olden, Kevin
• Is Part Of: ACG Case Reports Journal. Volume 6:Issue 10(2019)
• Publication Date: 2019-10
• DOI: 10.14309/crj.0000000000000256
• Languages: English
• ISSNs: 2326-3253

Abstract

Abstract : ABSTRACT: Gastroparesis is a chronic condition of delayed gastric emptying in the absence of mechanical outlet obstruction. We report a 47-year-old African American woman with diabetic gastroparesis who presented with intractable nausea, vomiting, and decreased oral intake with electrolyte disturbances. The patient's symptoms were difficult to control with antiemetic and conventional prokinetic agents, and she was started on mirtazapine 15 mg nightly. She experienced an almost complete symptom relief and was able to tolerate solid food within 24–48 hours. We highlight the role of mirtazapine, a 5-HT1a agonist, as an effective therapy for refractory gastroparesis.