Number concentrations of ultrafine particles and the incidence of postmenopausal breast cancer. Issue 1 (March 2018)

• Record Type: Journal Article
• Authors: Goldberg, Mark S.; Labrèche, France; Weichenthal, Scott; Lavigne, Eric; Valois, Marie-France; Hatzopoulou, Marianne; Shekarrizfard, Maryam
• Is Part Of: Environmental epidemiology. Volume 2:Issue 1(2018)
• Publication Date: 2018-03
• Subjects: Ultrafine particles -- Traffic-related air pollution -- Diesel exhaust -- Postmenopausal breast cancer -- Incidence -- Case–control study; Epidemiology -- Periodicals; Epidemiology -- Environmental aspects -- Periodicals; 614.4
• DOI: 10.1097/EE9.0000000000000006
• Languages: English
• ISSNs: 2474-7882

Abstract

Abstract : Background: There have been a number of reports regarding possible associations between the incidence of female breast cancer and ambient air pollution. Only one study has been published about possible association with ultrafine particles (UFPs; <0.1 μm). Methods: We conducted a case–control study of incident postmenopausal breast cancer in Montreal, Canada. Cases were identified between 1996 and 1997 from all hospitals that treated breast cancer. Controls were women diagnosed with other sites of cancer and frequency-matched to cases by hospital and 5-year age groups. Concentrations of UFPs were estimated using a land-use regression model developed in 2011–2012 and assigned to women's residential addresses at time of diagnosis. Odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using logistic regression models adjusting for individual-level and ecological covariates. Results: We found that the response functions between UFPs and incident, postmenopausal breast cancer were consistent with linearity. Adjusted ORs of 1.08 (95% CI = 0.96, 1.21) were found for an increase in UFPs equal to the interquartile range (IQR). We found higher ORs among cases with positive estrogen (ER+) and negative progesterone receptor (PR−) (OR = 1.23; 95% CI = 1.04–1.45) and for women with ER−/PR− status (OR = 1.23; 95% CI = 0.99–1.54). We also found stronger associations when analyses were restricted to those women who had not lived at their current address for 10 years or more (OR = 1.27; 95% CI = 0.94–1.71). Conclusions: Our findings suggest that exposure to ambient UFPs may increase the risk of incident postmenopausal breast cancer, especially among cases with ER+/PR− and ER−/PR− receptor status. Abstract : Supplemental Digital Content is available in the text.