Modulatory Effects of Pregnancy on Inflammatory Bowel Disease. Issue 3 (March 2019)

• Record Type: Journal Article
• Authors: van der Giessen, Janine; Huang, Vivian W.; van der Woude, C. Janneke; Fuhler, Gwenny M.
• Is Part Of: Clinical and translational gastroenterology. Volume 10:Issue 3(2019)
• Publication Date: 2019-03
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology; Gastrointestinal Diseases; Liver Diseases; Intestines -- Diseases; Stomach -- Diseases; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; Electronic journals; 616.33
• DOI: 10.14309/ctg.0000000000000009
• Languages: English
• ISSNs: 2155-384X

Abstract

Abstract : The disease course of autoimmune diseases such as rheumatoid arthritis is altered during pregnancy, and a similar modulatory role of pregnancy on inflammatory bowel disease (IBD) has been proposed. Hormonal, immunological, and microbial changes occurring during normal pregnancy may interact with the pathophysiology of IBD. IBD consists of Crohn's disease and ulcerative colitis, and because of genetic, immunological, and microbial differences between these disease entities, they may react differently during pregnancy and should be described separately. This review will address the pregnancy-induced physiological changes and their potential effect on the disease course of ulcerative colitis and Crohn's disease, with emphasis on the modulation of epithelial barrier function and immune profiles by pregnancy hormones, microbial changes, and microchimerism.