Distal Ileal Ulcers as Gastrointestinal Manifestation of Waldenstrom Macroglobulinemia. Issue 4 (April 2019)

• Record Type: Journal Article
• Authors: Kantamaneni, Vamsi; Gurram, Krishna; Khehra, Raman; Koneru, Gopala; Kulkarni, Abhijit
• Is Part Of: ACG Case Reports Journal. Volume 6:Issue 4(2019)
• Publication Date: 2019-04
• DOI: 10.14309/crj.0000000000000058
• Languages: English
• ISSNs: 2326-3253

Abstract

Abstract : ABSTRACT: Waldenstrom macroglobulinemia (WM) is a neoplastic disorder of the B-cell lymphoid system. A 69-year-old man with WM presented with diarrhea for 6 months. Magnetic resonance enterography showed thickening of the terminal ileum (TI). Colonosocopy with TI intubation showed a single TI ulcer, and small bowel enteroscopy revealed multiple ulcers in the TI. Biopsies from both were negative on hematoxylin and eosin staining. Immunoglobulin M immunofluorescence staining of the ulcers was positive for IgM deposits consistent with WM. After 6 cycles of chemotherapy with bendamustine and rituximab, symptoms resolved.