Safety of Endoscopy in Heritable Connective Tissue Disorders. (August 2019)

• Record Type: Journal Article
• Authors: Kilaru, Saikiran M.; Mukamal, Kenneth J.; Nee, Judy W.; Oza, Sveta S.; Lembo, Anthony J.; Wolf, Jacqueline L.
• Is Part Of: American journal of gastroenterology. Volume 114:Number 8(2019)
• Publication Date: 2019-08
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000000189
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : Introduction: Little is known about the gastrointestinal manifestations or safety of endoscopy among patients with heritable connective tissue disorders such as Marfan syndrome or Ehlers-Danlos syndrome (EDS). Methods: We conducted an electronic cross-sectional survey nested within preexisting registries of patients with heritable connective tissue disorders and examined self-reported rates of endoscopic complications. Results: The rate of endoscopy-related perforation was 9.4% (95% confidence interval 2.0%–25.0%) among individuals with vascular EDS, <1% in classical and hypermobility-type EDS, and zero in Marfan syndrome ( P < 0.001). Spontaneous intestinal perforation was also significantly higher in the vascular EDS group. DISCUSSION: Clinicians should consider noninvasive screening methods for patients with vascular EDS.