Hepatitis B Virus and HIV Coinfection: Fibrosis, Fat, and Future Directions. (May 2019)

• Record Type: Journal Article
• Authors: Kim, Arthur Y.
• Is Part Of: American journal of gastroenterology. Volume 114:Number 5(2019)
• Publication Date: 2019-05
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000000231
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : Abstract: HIV and hepatitis B virus (HBV) share routes of transmission, and coinfection is associated with higher levels of HBV DNA, accelerated fibrosis progression, and increased liver-related events compared with those with HBV alone. The full spectrum of hepatic histology has not been recently addressed, in part because of the decreasing use of liver biopsy in clinical practice. The current study provides a modern "snapshot" of biopsy data from 114 HIV/HBV coinfected individuals, elucidating the degree of liver fibrosis years into the effective antiretroviral era and also revealing that hepatic steatosis was a frequent finding.