ANCA-Associated Intrahepatic Duct Injury Associated with Levamisole-Adulterated Cocaine. (23rd December 2020)

• Record Type: Journal Article
• Authors: Salabei, Joshua K.; Khan, Sara; Khan, Afzal; Asnake, Zekarias T.; Fishman, Troy J.; Stromas, Jonathan D.; Ismail, Zeeshan H.; Leibach, John R.
• Other Names: Snyder Ned Academic Editor.
• Is Part Of: Case reports in hepatology. Volume 2020(2020)
• Publication Date: 2020-12-23
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; Liver Diseases; Liver; Liver; Liver -- Diseases; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.36
• DOI: 10.1155/2020/8867183
• Languages: English
• ISSNs: 2090-6587

Abstract

Abstract : Damage to the liver or kidney can occur through direct toxic effects; however, damage can also be drug-induced immune-mediated. Levamisole-adulterated cocaine (LAC) is known to cause antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis and glomerulonephritis leading to acute kidney injury and end-stage renal disease. It remains unclear whether LAC is associated with hepatic duct damage. Here, we report a case with biopsy-proven evidence of intrahepatic duct damage months after being diagnosed with ANCA-associated crescentic and sclerosing glomerulonephritis caused by LAC use. This case represents the first report of LAC-induced ANCA-associated hepatic duct cholestasis in the setting of previous LAC-induced ANCA-positive glomerulonephritis.