Synthesis and Anti-inflammatory Activity of Some Novel Pyrazole Derivatives of Gallic Acid. Issue Volume 6:Issue S1(2009) (2009)

• Record Type: Journal Article
• Authors: Arunkumar, S.; Ilango, K.; Manikandan, R. S.; Ramalakshmi, N.
• Is Part Of: E-Journal of Chemistry. Volume 6:Issue S1(2009)
• Page Start: S123
• Page End: S128
• Publication Date: 2009
• Subjects: Gallic acid -- Chalcones -- Pyrazole -- Characterization -- Anti-inflammatory activity
• DOI: 10.1155/2009/128586
• Languages: English
• ISSNs: 0973-4945

Abstract

Abstract : In the present study, a new series of [5-substituted-3-(phenylamino)-1 H -pyrazol-1yl] (3, 4, 5-trihydroxyphenyl)-methanone (4a-j) have been synthesized. 3, 4, 5-Trihydroxy benzohydrazide (1) was synthesized from propyl gallate and hydrazine hydrate in presence of ethanol. Chalcones (2a-j) were synthesized from acetanilide and various aromatic aldehydes in presence of ethanol and sodium hydroxide solution. By refluxing the compound (1) and compounds (2a-j) in presence of ethanol yielded [5-substituted-3-(phenylamino)-4.5-dihydropyrazol-1yl] (3, 4, 5-trihydroxy phenyl)-methanone (3a-j). The final compounds [5-substituted-3-(phenylamino)-1 H -pyrazol-1yl] (3, 4, 5-trihydroxyphenyl)-methanone (4a-j) were synthesized by treating compounds (3a-j) with bromine water. The synthesized compounds have been characterized by IR, 1 HNMR and Mass spectral data. The compounds were evaluated for in vivo anti-inflammatory activity by carrageenan induced paw edema test. In general all compounds were found to exhibit good anti-inflammatory activity.