Expression of Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 mRNAs in Human Cortical Xenografts. (1995)

• Record Type: Journal Article
• Authors: Humpel, Christian; Strömberg, Ingrid; Olson, Lars
• Is Part Of: Journal of neural transplantation & plasticity. Volume 5:Number 4(1994)
• Page Start: 257
• Page End: 264
• Publication Date: 1995
• Subjects: Nerve tissue -- Transplantation -- Periodicals; Neuroplasticity -- Periodicals; Nerve tissue -- Transplantation; Neuroplasticity; Neuronal Plasticity -- Periodicals; Computer network resources; Periodicals; Electronic journals; 612.82
• DOI: 10.1155/NP.1994.257
• Languages: English
• ISSNs: 0792-8483

Abstract

Abstract : Trophic factors play an important role in the development of neurons and glia. In order to study the involvement of neurotrophins in human cortical development, human fetal parietal cortical tissue, obtained after early elective abortions, was transplanted to cortical cavities in immunosuppressed rats. Using in situ hybridization it was demonstrated that nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in developing human cortical xenografts. We conclude that neurotrophins may play a role in human cortical development and rat-derived astroglial cells could be involved in establishing reciprocal "permissive sites".