Synthesis and Biological Activity of Some new 2-Heterocyclic/acyclic amino/4'-acetamidophenoxy-3-(4-chloro-phenyl)-3, 4-dihydrobenzo[e]- [1, 3, 2]oxazaphosphinine 2-sulfides. Issue Volume 5:Issue S1(2008) (2008)

• Record Type: Journal Article
• Authors: Reddy, K. R. Kishore Kumar; Prasad, G. Syam; Kumar, M. Anil; Reddy, C. Suresh; Raju, C. Naga
• Is Part Of: E-Journal of Chemistry. Volume 5:Issue S1(2008)
• Page Start: 1025
• Page End: 1032
• Publication Date: 2008
• Subjects: 2-[(4-Chlorophenylamino) methyl] phenol -- Thiophosphoryl chloride -- Benzoxaza-phosphinine 2-sulfide -- Triethylamine/sodium hydride -- Antimicrobial activity
• DOI: 10.1155/2008/415030
• Languages: English
• ISSNs: 0973-4945

Abstract

Abstract : 2-Heterocyclic/acyclicamino/4'-acetamidophenoxy-3-(4-chlorophenyl)-3, 4-dihydrobenzo-[ e ][1, 3, 2]oxazaphosphinine 2-sulfides (4a-j) were synthesized through a two steps process. In the first step, 2-chloro-3-(4-chlorophenyl)-3, 4-dihydrobenzo[ e ] [1, 3, 2]-oxazaphosphinine 2-sulfide (2) was prepared by the reaction of 2-[(4-chlorophenylamino)methyl]phenol (1) with thiophosphoryl chloride in the presence of triethylamine in dry toluene-tetrahydrofuran. In the second step, 2 was treated with various heterocyclic/acyclicamines/4'-acetamidophenol in presence of triethylamine-/ sodium hydride in toluene-tetrahydrofuran at 45-50°C . All the synthesized compounds (4a-j) were characterized by elemental analysis, IR, NMR( 1 H, 13 C and 31 P) and mass spectra and their biological activity was evaluated for antimicrobial activity.