Preparation, characterization and wound healing effect of alginate/chitosan microcapsules loaded with polysaccharides from Nostoc Commune Vaucher. (17th February 2021)

• Record Type: Journal Article
• Authors: Yang, Mingjun; Li, Run; Wang, Xinjian; Liu, Xiaofeng; Zhang, Baigang; Wang, Yonggang
• Is Part Of: Biomedical materials. Volume 16:Number 2(2021)
• Publication Date: 2021-02-17
• Subjects: Nostoc commune Vaucher -- microcapsules -- wound healing; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1088/1748-605X/abd051
• Languages: English
• ISSNs: 1748-6041

Abstract

Abstract: Biologically active coating materials could promote the growth of granulation tissue as auxiliary materials, while natural polysaccharides could promote vascular regeneration and wound healing. Therefore, in this study, ultrasound-assisted extract of Nostoc commune Vaucher polysaccharides (UAP) yield after the process optimization was 12.89 ± 0.24%, which was used to prepare microcapsules by emulsification and cross-linking. The effect of alginate/chitosan-UAP composite materials on wound healing in an experimental rat model for 14 d and its physical properties were evaluated. In vitro experiments indicated that the UAP microcapsule material had a porous and loose three-dimensional network structure, and had good biocompatibility and swelling properties as a wound healing material. Animal experiments indicated that UAP microcapsules could extremely significantly promote wound healing ( P < 0.01), and wound closure rate reached 79.16 ± 3.91% on 14th day. Meanwhile UAP microcapsules might promote angiogenesis and granulation growth by enhancing immunity and increasing the expression of VEGF and miR-21. Therefore, the composites of UAP microcapsules have shown encouraging results as a potential dressing for wound healing.