Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma. (2010)

• Record Type: Journal Article
• Authors: Cano, Carla; Motoo, Yoshiharu; Iovanna, Juan L.
• Other Names: Iovanna Juan Academic Editor.; Neira José Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 10(2010)
• Page Start: 1947
• Page End: 1957
• Publication Date: 2010
• Subjects: cancer -- pancreas -- epithelial-to-mesenchymal transition -- TGFbeta -- metastasis; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2010.183
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Epithelial to mesenchymal transition (EMT) is a physiologic process that allows morphological and genetic changes of carcinoma cells from an epithelial to a mesenchymal phenotype, which is the basis of the high metastatic potential of pancreatic cancer cells. EMT is triggered by various tumor microenvironmental factors, including cytokines, growth factors, and chemotherapeutic agents. This review summarizes the state-of-the-art knowledge on the molecular mechanisms that support pancreatic cancer EMT and the evidences that support its involvement in invasiveness/aggressiveness, and the drug resistance of pancreatic cancer cells.