PSA and Beyond: The Past, Present, and Future of Investigative Biomarkers for Prostate Cancer. (2010)

• Record Type: Journal Article
• Authors: Tosoian, Jeffrey; Loeb, Stacy
• Other Names: Eggener Scott Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 10(2010)
• Page Start: 1919
• Page End: 1931
• Publication Date: 2010
• Subjects: prostate cancer -- biomarkers -- screening -- diagnosis -- prostatic acid phosphatase -- prostate-specific antigen (PSA) -- PSA density -- free PSA -- PSA kinetics -- PSA isoforms -- PCA3 -- GSTP-1 -- AMACR -- single nucleotide polymorphism (SNP); Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2010.182
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : The discovery of prostate-specific antigen (PSA) as a biomarker represented a major discovery in the early diagnosis and monitoring of prostate cancer. However, the use of PSA is limited by the lack of specificity and an inability to differentiate indolent from life-threatening disease reliably at the time of diagnosis. A multitude of studies have aimed to improve the performance of PSA as well as identify additional biomarkers. The purpose of this study is to review available data on prostate cancer biomarkers for prostate cancer screening and prognostication, including prostatic acid phosphatase, PSA, PSA derivatives (PSA density, free PSA, pro PSA, and PSA kinetics), PCA3, GSTP1, AMACR, and other newly emerging molecular and genetic markers.