Synthesis, Spectral Characterization and Evaluation of Pharmacodynamic Activity of Copper and Nickel Complexes of Ethambutol Dihydrochloride. Issue 4 (2006)

• Record Type: Journal Article
• Authors: Annapurna, M. Mathrusri; Rao, M. E. Bhanoji; Kumar, B. V. V. Ravi
• Is Part Of: E-Journal of Chemistry. Volume 3:Issue 4(2006)
• Page Start: 274
• Page End: 277
• Publication Date: 2006
• Subjects: Ethambutol -- Ligand -- Metal complex -- Anti-tubercular activity -- MABA
• DOI: 10.1155/2006/476513
• Languages: English
• ISSNs: 0973-4945

Abstract

Abstract : Nickel and copper complexes of ethambutol [EB] were synthesized and characterized. On the basis of spectral and thermal data an octahedral geometry was assigned to the complexes with molecular formulae [Cu(C10 H24 N2 O2 )2 Cl2 ] 5H2 O and [Ni(C10 H24 N2 O2 )2 Cl2 ] 2H2 O. Coordination of ethylene diamine derivative to the metal ion was proposed. The anti-tubercular activity of the complexes was evaluated using Lowenstein–Jensen medium and MABA [Microplate Alamar Blue Assay] methods.