Artificial Organelles: Digital Microfluidic Platform for Proteoglycan and Glycoprotein Biosynthesis. (2010)

• Record Type: Journal Article
• Authors: Martin, Jeffrey G.; Beaudet, Julie M.; Dordick, Jonathan S.; Linhardt, Robert J.
• Other Names: Goette Martin Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 10(2010)
• Page Start: 997
• Page End: 1000
• Publication Date: 2010
• Subjects: artificial organelle -- Golgi -- endoplasmic reticulum -- proteoglycan -- glycoprotein -- glycosaminoglycan -- heparin -- heparan sulfate -- digital microfluidics; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2010.95
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : The development of artificial organelles is a new, fast-growing field in which a variety of techniques have been employed. This article gives a brief overview of the history of artificial organelles, and describes the development of an artificial endoplasmic reticulum and Golgi organelle on a digital microfluidic platform. This device should be useful in high-throughput combinatorial proteoglycan/glycoprotein synthesis, providing critical information about the control of biosynthetic pathways for these important signaling molecules.