The DNA Polymerase ʱ-Primase Complex: Multiple Functions and Interactions. (2003)

• Record Type: Journal Article
• Authors: Muzi-Falconi, Marco; Giannattasio, Michele; Foiani, Marco; Plevani, Paolo
• Other Names: Learmonth Robert P. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 3(2003)
• Page Start: 21
• Page End: 33
• Publication Date: 2003
• Subjects: DNA polymerase a -- DNA primase -- DNA replication -- checkpoints -- DNA repair -- chromatin -- yeast; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2003.05
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : DNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.