Stability Indicating Analytical Method Development and Validation of Efavirenz Quantification by High Performance Liquid Chromatographic Technique. Issue 4 (2011)
- Record Type:
- Journal Article
- Title:
- Stability Indicating Analytical Method Development and Validation of Efavirenz Quantification by High Performance Liquid Chromatographic Technique. Issue 4 (2011)
- Main Title:
- Stability Indicating Analytical Method Development and Validation of Efavirenz Quantification by High Performance Liquid Chromatographic Technique
- Authors:
- Kumar, R.
Sharma, M.
Verma, G. R. - Abstract:
- Abstract : A stability-indicating high performance liquid chromatography (HPLC) method is developed for the quantification of efavirenz drug substance. Selected mobile phase is a combination of 50 volume of acetonitrile and 50 volume of 0.86% w/v solution of ammonium dihydrogen phosphate, pH adjusted to 3.0 with orthophosphoric acid. Optimized column is a stainless steel column packed with base deactivated octa decylsilyl silica gel and at 252 nm wavelength. Linearity of the method is found 40 μg/mL to 160 μg/mL with regression coefficient of 0.9995. The method is validated according to ICH guidelines.
- Is Part Of:
- E-Journal of Chemistry. Volume 8:Issue 4(2011)
- Journal:
- E-Journal of Chemistry
- Issue:
- Volume 8:Issue 4(2011)
- Issue Display:
- Volume 8, Issue 4 (2011)
- Year:
- 2011
- Volume:
- 8
- Issue:
- 4
- Issue Sort Value:
- 2011-0008-0004-0000
- Page Start:
- 1498
- Page End:
- 1503
- Publication Date:
- 2011
- Subjects:
- Efavirenz -- Liquid chromatography -- Antiretroviral -- Validation
- DOI:
- 10.1155/2011/605381 ↗
- Languages:
- English
- ISSNs:
- 0973-4945
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library HMNTS - ELD Digital store
- Ingest File:
- 15805.xml