Synthesis and Antimicrobial Screening of Quinazolone Containing Novel Heterocyclic Schiff Base and Azetidinone by Niementowski Reaction. Issue 2 (2005)

• Record Type: Journal Article
• Authors: Desai, A. R.; Roy, R. U.; Desai, K. R.
• Is Part Of: E-Journal of Chemistry. Volume 2:Issue 2(2005)
• Page Start: 101
• Page End: 108
• Publication Date: 2005
• Subjects: Niementowski reaction -- Quinazolone -- Schiff base -- Azetidinone -- Antibacterial -- Antifungal
• DOI: 10.1155/2005/796474
• Languages: English
• ISSNs: 0973-4945

Abstract

Abstract : Several 2-[2-{(4-substitutedbenzylidene)-phenyl}vinyl]-4-oxo-3, 4-dihydroquinazolone-6-sulfonicacid 4(a-l) and 2-[2-{4-(3-chloro-4-substituedphenyl-azetidin-2-one)-phenyl}vinyl]-4-oxo-3, 4-dihydroqui-nazolone-6-sulfonic acid 5(a-l) were synthesized by using conventional techniques and were screened for antibacterial and antifungal activity. The compounds showed good to moderate antimicrobial activity and were characterized on the basis of spectral analysis.