Cure of Limb-Threatening XDR Pseudomonas aeruginosa Infection: Combining Genome Sequencing, Therapeutic Drug Level Monitoring, and Surgical Debridement. (26th November 2020)

• Record Type: Journal Article
• Authors: Narayanasamy, Shanti; Nation, Roger L; Mahony, Andrew A; Grayson, M Lindsay; Kwong, Jason C; Sherry, Norelle L; Khumra, Sharmila; Ellis, Andrew G; Frauman, Albert G; Holmes, Natasha E
• Is Part Of: Open forum infectious diseases. Volume 8:Number 1(2021)
• Publication Date: 2020-11-26
• Subjects: XDR gram-negative -- fosfomycin -- colistin -- therapeutic drug monitoring -- osteomyelitis; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofaa572
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We describe a case of limb-threatening osteomyelitis and metalware infection with carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa successfully cured with aggressive surgical debridement and combined intravenous fosfomycin and colistin. Real-time therapeutic drug monitoring was used to maximize probability of efficacy and minimize potential for toxicity.