Regulation of Apoptosis in African Swine Fever Virus–Infected Macrophages. (2002)

• Record Type: Journal Article
• Authors: Zsak, Laslo; Neilan, John G.
• Is Part Of: TheScientificWorldjournal. Volume 2(2002)
• Page Start: 1186
• Page End: 1195
• Publication Date: 2002
• Subjects: African swine fever -- virus -- gene -- protein -- macrophage -- cell death -- apoptosis -- virulence -- host range -- pathogenesis -- immunology; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2002.214
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : A number of viruses have evolved antiapoptotic mechanisms to promote infected-cell survival, either to ensure efficient productive viral replication or to promote long-term survival of virus-infected cells. Recent studies identified critical African swine fever virus genes involved in the complex regulation of ASFV-host interactions. Here we review the present knowledge of the recently identified ASFV genes with special attention to those which affect viral virulence, host range, and pathogenesis by regulating viral-induced apoptotic mechanisms.