Cerebral Hemodynamic Changes during the Trigeminocardiac Reflex: Description of a New Animal Model Protocol. (2010)

• Record Type: Journal Article
• Authors: Sandu, N.; Cornelius, J.; Filis, A.; Nöthen, C.; Rasper, J.; Kulinsky, V. I.; Schaller, B. J.
• Other Names: Little Peter Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 10(2010)
• Page Start: 1416
• Page End: 1423
• Publication Date: 2010
• Subjects: trigeminocardiac reflex -- trigemino-cardiac reflex -- animal model -- oxygen-conserving reflex -- cerebral hemodynamic -- cerebral blood flow; Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/tsw.2010.136
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : The trigeminocardiac reflex (TCR) is a well-known brainstem reflex, first described in skull base and neurosurgery by the senior author in 1999, leading to reflex apnea, bradycardia, and changes of mean arterial pressure. There seem to be differences between peripheral and central stimulation of the TCR, and there is a lack of clear data about the cerebral hemodynamic changes during the TCR. However, the research of this reflex principally focused on clinical cases for peripheral and central stimulation during the last years, and on rabbits for peripheral stimulation several decades ago, so there was a need for an animal model that allows us to use the current state-of-the-art imaging methods. The new animal model protocol as introduced by the authors gives, for the first time, deep insights into the cerebral hemodynamic changes during the TCR and gives substantial evidence whether the TCR represents an oxygen-conserving reflex or not.