Electroencephalography complexity in infantile spasms and its association with treatment response. Issue 2 (February 2021)

• Record Type: Journal Article
• Authors: Chu, Yen-Ju; Chang, Chi-Feng; Weng, Wen-Chin; Fan, Pi-Chuan; Shieh, Jiann-Shing; Lee, Wang-Tso
• Is Part Of: Clinical neurophysiology. Volume 132:Issue 2(2021)
• Page Start: 480
• Page End: 486
• Publication Date: 2021-02
• Subjects: Epilepsy -- West syndrome -- EEG complexity -- Multiscale entropy; ACTH adrenocorticotropic hormone -- AED anti-epileptic drug -- MSE multiscale entropy -- IQR inter-quarter range; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.12.006
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: The total EEG complexity is a potential biomarker of infantile spasms. Higher total EEG complexity before AED and 6 months after ACTH is associated with spasm-freedom. The total EEG complexity is not associated with the presence of hypsarrhythmia. Abstract: Objective: To investigate the potential of EEG multiscale entropy and complexity as biomarkers in infantile spasms. Methods: We collected EEG data retrospectively from 16 newly diagnosed patients, 16 age- and gender-matched healthy controls, and 15 drug-resistant patients. The multiscale entropy (MSE) and total EEG complexity before anti-epileptic drug (AED) treatment, before adrenocorticotropic hormone (ACTH) treatment, 14 days after ACTH therapy, and after 6 months of follow-up were calculated. Results: The total EEG complexity of 16 newly diagnosed infantile spasms patients was lower than the 16 healthy controls (median [IQR]: 351.5 [323.1–388.1] vs 461.6 [407.7–583.4]). The total EEG complexity before treatment was higher in the six patients with good response to AED than the 10 patients without response (median [IQR]: 410.0 [388.1–475.0] vs 344.5 [319.6–352.0]). The total EEG complexity before and after 14-days of ACTH therapy was not different between 13 ACTH therapy responders and nine non-responders. After 6-months follow-up, the total EEG complexity of ACTH therapy responders were higher than non-responders (median [IQR]: 598.5 [517.4–623.3] vs 448.6 [347.1–536.3]). Conclusions: The total EEG complexity before AED and 6 months after ACTH are associated with spasm-freedom. Significance: The total EEG complexity is a potential biomarker to predict and monitor the treatment effect in infantile spasms.