Mukaiyama's reagent promoted mild protocol for one-pot metal-free synthesis of dihydro quinazolinones. (16th February 2021)

• Record Type: Journal Article
• Authors: Rajput, Chatrasal S.; Srivastava, Shweta; Kumar, Ashish; Pathak, Arunendra
• Is Part Of: Tetrahedron letters. Volume 65(2021)
• Publication Date: 2021-02-16
• Subjects: Mukaiyama's reagent -- Dihydroquinazolin-4(1H)-ones -- 3-Phenyl-dihydroquinazolin-4(1H)-one -- Anthranilamide; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152791
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Mukaiyama's reagent one-pot highly selective synthesis of quinazolinones. Metal Catalyst free condition. High reaction efficiency. This reaction features simple starting materials and a broad substrate scope. Abstract: We have developed a fast and convenient method to prepare dihydroquinazolin-4(1H)-ones from anthranilamide and different aromatic aldehydes by using the Mukaiyama reagent. The reactions proceeded smoothly with a broad scope of substrates providing the expected products in good to excellent yields under with a low environmental factor and high atom economy. The metal-free condition and the ease of product isolation are the highlighted advantages in solving the issue of trace metal contamination in synthesized pharmaceuticals.