A comprehensive review on the biological interest of quinoline and its derivatives. (15th February 2021)

• Record Type: Journal Article
• Authors: Matada, Basavarajaiah Suliphuldevara; Pattanashettar, Raviraj; Yernale, Nagesh Gunavanthrao
• Is Part Of: Bioorganic & medicinal chemistry. Volume 32(2021)
• Publication Date: 2021-02-15
• Subjects: Heterocyclic compounds -- Quinolines -- Natural sources -- Marketed drugs -- Approved drugs -- Biological Interest; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2020.115973
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Figure A: Natural sources, Drug Candidates and Biological Interest of Quinoline and its derivatives. Abstract: Amongst heterocyclic compounds, quinoline is an advantaged scaffold that appears as a significant assembly motif for the development of new drug entities. Quinoline and its derivatives tested with diverse biological activity constitute an important class of compounds for new drug development. Therefore, many scientific communities have developed these compounds as intent structure and evaluated their biological activities. The present, review provides brief natural sources of quinoline and including a new extent of quinoline-based marketed drugs. This review also confers information about the biological activities of quinoline derivatives such as antibacterial, antifungal, antimycobacterial, antiviral, anti-protozoal, antimalarial, anticancer, cardiovascular, CNS effects, antioxidant, anticonvulsant, analgesic, anti-inflammatory, anthelmintic and miscellaneous activities.