A copper-catalyzed approach for the synthesis of asymmetrical disubstituted 1, 2, 4-thiadiazoles via elemental sulfur-mediated decarboxylative redox cyclization. (16th February 2021)

• Record Type: Journal Article
• Authors: Liu, Yafei; Zhang, Yurong; Zhang, Jun; Hu, Liang; Han, Shiqing
• Is Part Of: Tetrahedron letters. Volume 65(2021)
• Publication Date: 2021-02-16
• Subjects: 1, 2, 4-Thiadiazoles -- Elemental sulfur -- Arylacetic acids -- Redox reaction -- Copper-catalyzed; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152744
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: The synthetic method of asymmetrical disubstituted 1, 2, 4-thiadiazoles mediated by element sulfur. Copper is as a catalyst in this method. The yield was moderate to good. Abstract: The variety of asymmetrical disubstituted 1, 2, 4-thiadiazoles are smoothly prepared by copper-catalyzed approach, which employed arylacetic acids and amidines as substrates, and elemental sulfur to mediate decarboxylative redox cyclization. The advantages of this method are simple, efficient, and ligand-free. In addition, this method can provide products in moderate to good yields.